Sperm ion channels and transporters in male fertility and infertility

H Wang, LL McGoldrick, JJ Chung - Nature Reviews Urology, 2021 - nature.com
… In this Review, we explore the literature regarding ion channel signalling in the context of
regulating mammalian sperm motility and male fertility, focusing on sperm ion channels and …

Structure and function of ion channels regulating sperm motility—an overview

K Nowicka-Bauer, M Szymczak-Cendlak - International journal of …, 2021 - mdpi.com
… acquisition, maintenance, and modulation are essential for male fertility. The first steps of …
found to positively regulate sperm activation (T-type) and total and progressive motility (L-type) […

Human sperm ion channel (dys) function: implications for fertilization

SG Brown, SJ Publicover, CLR Barratt… - Human reproduction …, 2019 - academic.oup.com
sperm ion channels in human fertilization as evidenced from recent studies of sperm from
infertile men… CatSper in human sperm, and what is the consequence for male fertility for human …

The Catsper channel and its roles in male fertility: a systematic review

X Sun, Y Zhu, L Wang, H Liu, Y Ling, Z Li… - Reproductive Biology and …, 2017 - Springer
… Therefore, the Catsper ion channel has been implicated as a potential target for male infertility
… A significant decrease in sperm progressive motility was noticed after incubating cells with …

EMC10 governs male fertility via maintaining sperm ion balance

Y Zhou, F Wu, M Zhang, Z Xiong, Q Yin… - Journal of molecular …, 2018 - academic.oup.com
… mice, we accidentally found that male Emc10-deficient mice were … sperm maturation and
male fertility, and revealed the underlying mechanism by which EMC10 regulated the sperm

KCNQ1 potassium channel expressed in human sperm is involved in sperm motility, acrosome reaction, protein tyrosine phosphorylation, and ion homeostasis during …

T Gao, K Li, F Liang, J Yu, A Liu, Y Ni, P Sun - Frontiers in physiology, 2021 - frontiersin.org
… 293B showed lower sperm motility and progressive motility. … These potassium channels
may be able to help compensate if … channel in human sperm, its role in genetic male infertility

Major regulatory mechanisms involved in sperm motility

R Pereira, R Sá, A Barros, M Sousa - Asian Journal of Andrology, 2017 - journals.lww.com
… and is essential for hyperactivated motility and male fertility. … phosphorylation and in progressive
motility. Soluble AC is the … , possibly by the opening the ion channels (active state) and …

Introduction to the pathways involved in the activation and regulation of sperm motility: A review of the relevance of ion channels

DK Swain, P Sharma, N Shah, M Sethi… - Animal reproduction …, 2022 - Elsevier
… the capacity for motility (3); progressive motility is initiated … beating of flagella resulting in
progressive motility (4). This is … sperm motility may be important in addressing male infertility

[HTML][HTML] Ion channel gene expressions in infertile men: A case-control study

S Carkci, EO Etem, S Ozaydin, A Karakeci… - International Journal …, 2017 - ncbi.nlm.nih.gov
ion channels have an effect on sperm progressive motility … of the ion channels may be related
to male infertility especially by … There is a need for detailed evaluation in future studies with …

The role of sperm membrane potential and ion channels in regulating sperm function

FM Pinto, A Odriozola, L Candenas… - International Journal of …, 2023 - mdpi.com
reproduction technology (ART) as well [4,5,6,7,8,9,10,11]. However, the diagnosis of male
infertility remains mainly based on semen … morphology and progressive motility but were …